丁野　純男｜薬学部薬学科｜教員紹介｜北海道科学大学研究者データベース

チョウノ　スミオ Sumio Chono
丁野　純男

所属北海道科学大学薬学部薬学科

職種教授

著書・論文歴
著書	新発想製剤学-剤形,その理論,そして臨床へ-第３版 (単著) 2021/09
著書	新発想製剤学　厳選演習問題　第３版 (単著) 2021/08
著書	次世代吸入製剤とデバイスの開発 (共著) 2018/11
著書	新発想製剤学-剤形,その理論,そして臨床へ-第２版京都廣川書店 (単著) 2017/03
著書	新発想製剤学厳選演習問題第２版京都廣川書店 (単著) 2017/03
著書	NEWパワーブック生物薬剤学第３版-第2章薬物の吸収廣川書店 (共著) 2015/12
著書	新発想製剤学厳選演習問題京都廣川書店 (単著) 2014/09
著書	多面的症例解析演習―基礎分野・臨床分野から症例を俯瞰して…―気管支喘息京都広川書店 (共著) 2014/04
著書	新発想製剤学―剤形,その理論,そして臨床へ― 京都廣川書店 (単著) 2013/10
著書	DDS製剤の開発・評価と実用化手法 (共著) 2013/03
著書	症例まるごと基礎から解析第２版－臨床薬学総論患者ケアへのアプローチ－気管支喘息、COPD 京都広川書店 (共著) 2010/04
論文	Heterogenous intrapulmonary distribution of aerosolized model compounds in mice with bleomycin-induced pulmonary fibrosis J. Aerosol Med. Pulm. Drug Deliv. in press (共著) 2024
論文	スティックタイプ服薬補助ゼリーの離水に及ぼす「揉み込み」の影響臨床と研究 (共著) 2024
論文	半錠化したSSRI錠の保存安定性臨床と研究 (共著) 2024
論文	スティック包装された経口ゼリー剤を揉み込む行為がゼリーからの離水を誘発する新薬と臨床 72 (12),1015-1020頁 (共著) 2023/12
論文	Development of a compensated Förster resonance energy transfer imaging for improved assessment of the intrapulmonary distribution of polymeric nanoparticles J. Pharm. Sci. 112,2696-2702頁 (共著) 2023/10
論文	Development of LOX-1 antibody modified immuno-liposomes as drugcarriers to macrophages in atherosclerotic lesions Die Pharmazie 78,113-116頁 (共著) 2023/08
論文	チアパックタイプ服薬補助ゼリーの離水に及ぼす諸要因臨床と研究 100,92-98頁 (共著) 2023/08
論文	Development of visualization and analysis methods for evaluating intratumoral nanoparticle kinetics for tumor-targeted drug delivery using Förster resonance energy transfer in vivo live imaging and tissue clearing techniques Journal of Pharmaceutical and Biomedical Analysis 223,115127-11527頁 (共著) 2023/01
論文	Improvement of the pharmacokinetics and antifibrotic effects of nintedanib by intrapulmonary administration of a nintedanib–hydroxypropyl-γ-cyclodextrin inclusion complex in mice with bleomycin-induced pulmonary fibrosis Eur. J. Pharm.Biopharm. 172,203-212頁 (共著) 2022/03
論文	Aerosolized liposomal formulation prevents enhanced drug transfer from fibrotic lungs to the systemic circulation Curr. Drug Deliv. 18,923-930頁 (共著) 2021/10
論文	北海道産赤ビーツによる便通異常の改善効果についての検討応用薬理 100,95-100頁 (共著) 2021/09
論文	大学統合により北海道薬科大学から北海道科学大学へ薬剤学 81 (2),143-149頁 (単著) 2021/04
論文	北海道の地域性に根ざした産学官連携産学官連携ジャーナル,16-19頁 (単著) 2021/04
論文	Evaluationoftissue-clearingtechniquesforintraorganimagingofdistributionofpolymericnanoparticlesasdrugcarriers Drug Dev. Ind. Pharm. (共著) 2020/12
論文	MultiscaleliveimagingusingFrsterResonanceEnergyTransfer(FRET)forevaluatingthebiologicalbehaviorofnanoparticlesasdrugcarriers J. Pharm. Sci. (共著) 2020/12
論文	Three-dimensionalimagingofpulmonaryfibroticfociatthealveolarscaleusingtissue-clearingtreatmentwithstainingtechniquesofextracellularmatrix Int. J. Biomed. Imaging 2020,1-9頁 (共著) 2020/12
論文	ProlongeddistributionofaerosolizedPEGylatedliposomesinthelungsofmicewithbleomycin-inducedpulmonaryfibrosis Drug Dev. Ind. Pharm. 46,1873-1880頁 (共著) 2020/11
論文	Assessmentoftransporter-mediatedeffluxofnintedanibusinginvitrocelllinemodelsofidiopathicpulmonaryfibrosis Die Pharmazie 75,371-374頁 (共著) 2020/08
論文	Intratumoral delivery and therapeutic efficacy of nanoparticle-encapsulated anti-tumor siRNA following intrapulmonary administration for potential treatment of lung cancer Pharm. Dev. Technol. 24,1095-1103頁 (共著) 2019/11
論文	Conditional examinations for pulverization of lansoprazole orally disintegrating tablets J. Generic Med. 15,99-103頁 (共著) 2019/09
論文	Evaluation of various tissue-clearing techniques for the three-dimensional visualization of liposome distribution in mouse lungs at the alveolar scale Int. J. Pharm. 562,218-227頁 (共著) 2019/05
論文	Effect of water temperature on the simple suspension method for a branded and five generic lansoprazole orally disintegrating tablets J. Generic Med. 15 (1),4-9頁 (共著) 2019/01
論文	Usability of theophylline extended-release dry syrups J. Generic Med. 14 (4),175-179頁 (共著) 2018/12
論文	Taste and dissolution of theophylline extended-release dry syrups J. Generic Med. 14 (3),117-121頁 (共著) 2018/09
論文	ランソプラゾール口腔内崩壊錠の後発品の粉砕可否に関する検討応用薬理 94 (5/6.),67-70頁 (共著) 2018/07
論文	Facile and sensitive HPLC-UV method for determination of nintedanib in rat plasma Int. J. Pharm. Pharm. Sci. 10 (6),133-137頁 (共著) 2018/05
論文	テオフィリン徐放性シロップ用剤の製剤物性および服用性の一例応用薬理 94 (3/4.),53-57頁 (共著) 2018/04
論文	ランソプラゾール口腔内崩壊錠の後発品に対する簡易懸濁法の適用可否応用薬理 94 (3/4.),33-35頁 (共著) 2018/04
論文	研究をやってみせんか？（４）論文発表と研究小話道薬誌 (単著) 2018/03
論文	研究をやってみせんか？（３）研究の実践と学会発表道薬誌 (単著) 2018/02
論文	Tissue-clearing techniques enable three-dimensional visualization of aerosolized model compound and lung structure at the alveolar scale Biol. Pharm. Bull., 41,,24-28頁 (共著) 2018/01
論文	研究をやってみせんか？（２）学会参加と研究計画立案道薬誌 (単著) 2018/01
論文	研究をやってみませんか？（１）6年制薬学教育の「薬学研究」道薬誌, 34(12)-35(3) (単著) 2017/12
論文	Aerosolized liposomes with dipalmitoyl phosphatidylcholine enhance pulmonary absorption of encapsulated insulin compared with co-administered insulin Drug Dev. Ind. Pharm., 43,,1892-1898頁 (共著) 2017/11
論文	Inhibitory effect of young barley grass extract powder on body weight increase and visceral fat accumulations of mice fed high-fat diet Pharmacometrics, 93 (1/2.),13-18頁 (共著) 2017/11
論文	Evaluation of permeability alteration and epithelial–mesenchymal transition induced by transforming growth factor-β1 in A549, NCI-H441, and Calu-3 cells: Development of an in vitro model of respiratory epithelial cells in idiopathic pulmonary fibrosis J. Pharmacol. Toxicol. Methods, 86,,19-27頁 (共著) 2017/07
論文	Physical properties of lansoprazole orally disintegrating tablets J. Generic Med. 13 (1),5-8頁 (共著) 2017/03
論文	Physicochemical quality and ingestibility of high value-added amlodipine besilate formulations J. Generic Med. 13 (1),28-33頁 (共著) 2017/03
論文	Storage stability of serum formulations containing ofloxacin for autologous serum eardrop therapy Pharmazie 72 (3),139-142頁 (共著) 2017/03
論文	Ingestibility and formulation quality of lansoprazole orally disintegrating tablets J. Pharm., 2016, Article ID 6131608, 6 pages (共著) 2016/12
論文	フェキソフェナジンの消化管吸収における配合薬プソイドエフェドリン及び栄養成分の影響応用薬理 91 (3/4.),69-76頁 (共著) 2016/10
論文	ランソプラゾールOD錠の先発品と後発品の物理的品質の比較医薬品医療機器レギュラトリーサイエンス 47 (10),760-764頁 (共著) 2016/10
論文	研究の軸足を「基礎的研究」と「臨床的研究」の双方に置いて〜製剤・DDSを「作り」・「活かす」ために〜製剤機械技術学会誌 25 (3),37-44頁 (単著) 2016/09
論文	Sustained distribution of aerosolized PEGylated liposomes in epithelial lining fluid on alveolus surface Drug Deliv. Transl. Res., 6,,565-571頁 (共著) 2016/08
論文	Hydrophilia, tablet strength, and pushing out by pressing through the package of acarbose and rebamipide orally disintegrating tablets Pharmacometrics, 90 (5/6.),83-85頁 (共著) 2016/06
論文	Tumor distribution and anti-tumor effect of doxorubicin following intrapulmonary administration to mice with metastatic lung tumor J. Drug Deliv. Sci. Tech., 33,,143-148頁 (共著) 2016/06
論文	タムスロシン塩酸塩口腔内崩壊錠0.1 mgの製剤品質および服用性の臨床的評価ジェネリック研究 10 (1),27-34頁 (共著) 2016/06
論文	ヒト官能試験による口腔内崩壊錠の服用性の実証臨床と研究 93 (5),171-174頁 (共著) 2016/05
論文	Alteration in intrapulmonary pharmacokinetics of aerosolized model compounds due to disruption of the alveolar epithelial barriers following bleomycin-induced pulmonary fibrosis in rats J. Pharm. Sci. 105 (3),1327-1334頁 (共著) 2016/03
論文	ドライシロップ剤の使用者は「味」と「水との混ざりやすさ」を重視する小児科診療 79 (1),128-132頁 (共著) 2016/01
論文	テオフィリン徐放錠の薬物溶出特性とin silico血中濃度推移シミュレーション臨床医薬 31 (9),835-841頁 (共著) 2015/09
論文	簡易懸濁法の実施が困難な低分散性固形医薬品に対するバッグ型注入器の有用性医学と薬学 72 (8),1371-1378頁 (共著) 2015/08
論文	薬剤学概史北海道薬科大学の薬剤学の歩みじほう (単著) 2015/05
論文	Efficient Delivery to Human Lung Fibroblasts (WI-38) of Pirfenidone Incorporated into Liposomes Modified with Truncated Basic Fibroblast Growth Factor and Its Inhibitory Effect on Collagen Synthesis in Idiopathic Pulmonary Fibrosis Biol. Pharm. Bull. 38 (2),270-276頁 (共著) 2015/02
論文	Involvement of intestinal permeability in the oral absorption of clarithromycin and telithromycin Biopharm. Drug Dispos. 38 (2),270-276頁 (共著) 2014/09
論文	Aerosol-based efficient delivery of azithromycin to alveolar macrophages for treatment of respiratory infections Pharm. Dev. Technol., 18,,1361-1365頁 (共著) 2013/11
論文	Subcellular distribution of azithromycin and clarithromycin in rat alveolar macrophages (NR8383) in vitro Biol. Pharm. Bull., 36,,1494-1499頁 (共著) 2013/09
論文	薬剤師が知っておきたいDDS製剤の機能とメカニズム薬局薬学,1-14頁 (単著) 2013/05
論文	Enantioselective uptake of fexofenadine by Caco-2 cells as model intestinal epithelial cells J. Pharm. Pharmacol., 65,,22-29頁 (共著) 2013/01
論文	リポソームによるDDSを利用した各種難治性疾患の革新的治療戦略医薬品相互作用研究, 36,,1-12頁 (単著) 2012/09
論文	Transport characteristics of clarithromycin, azithromycin and telithromycin, antibiotics applied for treatment of respiratory infections, in Calu-3 cell monolayers as model lung epithelial cells Pharmazie, 67,,389-393頁 (共著) 2012/05
論文	Aerosol-based efficient delivery of clarithromycin, a macrolide antimicrobial agent, to lung epithelial lining fluid and alveolar macrophages for treatment of respiratory infections J. Aerosol Med. Pulm. Drug Deliv., 25,,110-115頁 (共著) 2012/04
論文	呼吸器感染症の治療を目的としたマクロライド系抗菌薬の肺内動態及び肺移行機構に関する研究化学療法の領域 27 (12),2754-2761頁 (共著) 2011/12
論文	Distribution characteristics of clarithromycin and azithromycin, macrolide antimicrobial agents used for treatment of respiratory infections, in lung epithelial lining fluid and alveolar macrophages Biopharm. Drug Dispos., 32,,389-397頁 (共著) 2011/08
論文	Efficient drug delivery to lung epithelial lining fluid by aerosolization of ciprofloxacin incorporated into PEGylated liposomes for treatment of respiratory infections Drug Dev. Ind. Pharm., 37,,367-372頁 (共著) 2011/04
論文	Effects of Sperminated Pullulans on the Pulmonary Absorption of Insulin Yakugaku Zasshi, 131,,307-314頁 (共著) 2011/02
論文	DDSの基本的な概念と原理（４）注射型DDS及び次世代型DDSのサイエンスと薬物治療道薬誌 (共著) 2010/10
論文	DDSの基本的な概念と原理（３）皮膚・粘膜適用型DDSのサイエンスと薬物治療道薬誌 (共著) 2010/09
論文	DDSの基本的な概念と原理（２）経口DDS製剤のサイエンスと薬物治療道薬誌 (共著) 2010/08
論文	Aerosol-based efficient delivery of telithromycin, a ketolide antimicrobial agent, to lung epithelial lining fluid and alveolar macrophages Drug Dev. Ind. Pharm., 36,,861-866頁 (共著) 2010/07
論文	DDSの基礎的な概念と原理（１）DDS化のサイエンスと薬物治療道薬誌 27 (7-10.) (共著) 2010/07
論文	Effect of surface-mannose modification on aerosolized liposomal delivery to alveolar macrophages Drug Dev. Ind. Pharm., 36,,102-107頁 (共著) 2010/01
論文	Intracellular pharmacokinetics of telithromycin, a ketolide antibiotic, in alveolar macrophages J. Pharm. Pharmacol., 62,,71-75頁 (共著) 2010/01
論文	Distribution characteristics of telithromycin, a novel ketolide antimicrobial agent applied for treatment of respiratory infection, in lung epithelial lining fluid and alveolar macrophages Drug Metab. Pharmacokinet., 24,,411-417頁 (共著) 2009/10
論文	Aerosolized liposomes with dipalmitoyl phosphatidylcholine enhance pulmonary insulin delivery J. Control. Rel., 137,,104-109頁 (共著) 2009/07
論文	An efficient and low immunostimulatory nanoparticle formulation for systemic siRNA delivery to the tumor J. Control. Rel., 131,,64-69頁 (共著) 2008/10
論文	Efficient drug delivery to alveolar macrophages and lung epithelial lining fluid following pulmonary administration of liposomal ciprofloxacin in rats with pneumonia and estimation of its antibacterial effects Drug Dev. Ind. Pharm., 34,,1090-1096頁 (共著) 2008/10
論文	Efficient oncogene silencing and metastasis inhibition via systemic delivery of siRNA Mol. Ther., 16,,942-946頁 (共著) 2008/05
論文	Efficient drug targeting to rat alveolar macrophages by pulmonary administration of ciprofloxacin incorporated into mannosylated liposomes for the treatment of respiratory intracellular parasitic infections J. Control. Rel., 127,,50-58頁 (共著) 2008/04
論文	Spermined dextran, a cationized polymer, as absorption enhancer for pulmonary application of peptide drugs Pharmazie, 63,,180-184頁 (共著) 2008/03
論文	Design of cationic microspheres based on aminated gelatin for controlled release of peptide and protein drugs Drug Delivery, 15,,113-117頁 (共著) 2008/02
論文	Effects of sperminated polymers on the pulmonary absorption of insulin J. Control. Rel., 125,,246-251頁 (共著) 2008/02
論文	Efficient gene silencing in metastatic tumor by siRNA formulated in surface-modified nanoparticles J. Control. Rel., 126,,77-84頁 (共著) 2008/02
論文	Enhancement of the dissolution rate and gastrointestinal absorption of pranlukast as a model poorly water-soluble drug by grinding with gelatin Int. J. Pharm., 374,,71-78頁 (共著) 2008/01
論文	Development of drug delivery systems for targeting to macrophages Yakugaku Zasshi, 127,,1419-1430頁 (単著) 2007/09
論文	マクロファージを標的とするドラッグデリバリーシステムの構築薬学雑誌 (単著) 2007/09
論文	Pharmacokinetic and pharmacodynamic efficacy of intrapulmonary administration of ciprofloxacin for the treatment of respiratory infections Drug Metab. Pharmacokinet., 22,,88-95頁 (共著) 2007/04
論文	Effects of a sperminated gelatin on the nasal absorption of insulin Int. J. Pharm., 338,,213-218頁 (共著) 2007/01
論文	Uptake characteristics of liposomes by alveolar macrophages: Influence of particle size and surface mannose modification J. Pharm. Pharmacol., 59,,75-80頁 (共著) 2007/01
論文	Influence of particle size on drug delivery to rat alveolar macrophages following pulmonary administration of ciprofloxacin incorporated into liposomes J. Drug Targ., 14,,557-566頁 (共著) 2006/09
論文	Uptake of dexamethasone incorporated into liposomes by macrophages and foam cells and its inhibitory effect on cellular cholesterol ester accumulation J. Pharm. Pharmacol., 58,,1219-1225頁 (共著) 2006/09
論文	Effect of lecithin coating on the pulmonary absorption of furosemide in rats Biol. Pharm. Bull., 29,,1445-1448頁 (共著) 2006/07
論文	HFA 227-based metered dose inhaler containing furosemide coated with lecithin J. Drug Deliv. Sci. Technol., 16,,147-150頁 (共著) 2006/02
論文	Pharmacokinetic analysis of the uptake of liposomes by macrophages and foam cells in vitro and their distribution to atherosclerotic lesions in mice Drug Metab. Pharmacokinet., 21,,37-44頁 (共著) 2006/02
論文	Effect of cationized gelatins on the paracellular transport of drugs through caco-2 cell monolayers J. Pharm. Sci., 95,,1393-1401頁 (共著) 2006/01
論文	Influence of particle size on the distributions of liposomes to atherosclerotic lesions in mice Drug Dev. Ind. Pharm., 32,,125-135頁 (共著) 2006/01
論文	Aortic drug delivery of dexamethasone palmitate incorporated into lipid microspheres and its antiatherosclerotic effect in atherogenic mice J. Drug Targ., 13,,407-414頁 (共著) 2005/08
論文	Design of novel injectable cationic microspheres based on aminated gelatin for prolonged action of insulin J. Pharm. Pharmacol., 57,,839-844頁 (共著) 2005/07
論文	Efficient drug delivery to atherosclerotic lesions and the antiatherosclerotic effect by dexamethasone incorporated into liposomes in atherogenic mice J. Drug Targ., 13,,267-276頁 (共著) 2005/05
論文	Effect of aminated gelatin on the nasal absorption of insulin in rats Biol. Pharm. Bull., 28,,510-514頁 (共著) 2005/03
論文	Determination of diffusion coefficients of peptides and prediction of permeability through a porous membrane J. Pharm. Pharmacol., 56,,1501-1507頁 (共著) 2004/12
論文	Excised porcine skin experimental systems to validate quantitative microdialysis methods for determination of drugs in skin after topical application J. Control. Release, 100,,181-189頁 (共著) 2004/11
論文	Effect of camellia oil on the permeation of flurbiprofen and diclofenac sodium through rat and pig skin Biol Pharm. Bull., 27,,1476-1479頁 (共著) 2004/09
論文	Cellular uptake of dexamethasone palmitate-low density lipoprotein complex by macrophages and foam cells J. Drug Targ., 11,,163-168頁 (共著) 2003/04
論文	リポソーム製剤化によるデキサメタゾンの粥状動脈硬化病変部位への移行性と薬理効果の評価（博士論文） (単著) 2002/03
論文	Effect of dexamethasone palmitate-low-density lipoprotein complex on cholesterol ester accumulation in aorta of atherogenic model mice Biol. Pharm. Bull., 24,,925-929頁 (共著) 2001/08
論文	Inhibitiory effect of dexamethasone palmitate-low-density lipoprotein complex on low density lipoprotein-induced macrophage foam cell formation Biol. Pharm. Bull., 23,,466-471頁 (共著) 2000/04
論文	Effects of dexamethasone palmitate incorporated lipid emulsion on the experimental atherosclerosis Drug Delivery System, 14,,511-515頁 (共著) 1999/12
論文	Preparation of a complex of dexamethasone palmitate-low-density lipoprotein and its effect on foam cell formation of murine peritoneal macrophages J. Pharm. Sci., 88,,709-714頁 (共著) 1999/07
論文	パルミチン酸デキサメタゾン-リポ化製剤の粥状動脈硬化症に対する有用性に関する基礎的検討（修士論文） (単著) 1999/03