戸上　紘平｜薬学部薬学科｜教員紹介｜北海道科学大学研究者データベース

トガミ　コウヘイ Kohei Togami
戸上　紘平

所属北海道科学大学薬学部薬学科

職種准教授

著書・論文歴
論文	Development of a Compensated Förster Resonance Energy Transfer Imaging for Improved Assessment of the Intrapulmonary Distribution of Polymeric Nanoparticles. Journal of pharmaceutical sciences 112 (10),2696-2702 (共著) 2023/10
論文	Development of LOX-1 Antibody Modified Immuno-liposomes as Drug Carriers to Macrophages in Atherosclerotic Lesions. Die Pharmazie 78 (8),113-116 (共著) 2023/08
論文	Development of visualization and analysis methods for evaluating intratumoral nanoparticle kinetics for tumor-targeted drug delivery using Förster resonance energy transfer in vivo live imaging and tissue clearing techniques J Pharm Biomed Anal 223,115127 (共著) 2023/01
論文	Improvement of the pharmacokinetics and antifibrotic effects of nintedanib by intrapulmonary administration of a nintedanib-hydroxypropyl-γ-cyclodextrin inclusion complex in mice with bleomycin-induced pulmonary fibrosis. European journal of pharmaceutics and biopharmaceutics 172,203-212 (共著) 2022/03
論文	Aerosolized Liposomal Formulation Prevents Enhanced Drug Transfer from Fibrotic Lungs to the Systemic Circulation. Current drug delivery 18 (7),947-954 (共著) 2021/11
論文	Evaluation of tissue-clearing techniques for intraorgan imaging of distribution of polymeric nanoparticles as drug carriers Drug Dev. Ind. Pharm. (共著) 2020/12
論文	Multiscale Live Imaging Using Förster Resonance Energy Transfer (FRET) for Evaluating the Biological Behavior of Nanoparticles as Drug Carriers. Journal of pharmaceutical sciences 109 (12),3608-3616 (共著) 2020/12
論文	Three-Dimensional Imaging of Pulmonary Fibrotic Foci at the Alveolar Scale Using Tissue-Clearing Treatment with Staining Techniques of Extracellular Matrix. International journal of biomedical imaging 2020,8815231 (共著) 2020/12
論文	Prolonged distribution of aerosolized PEGylated liposomes in the lungs of mice with bleomycin-induced pulmonary fibrosis. Drug development and industrial pharmacy 46 (11),1873-1880 (共著) 2020/11
論文	Assessment of transporter-mediated efflux of nintedanib using in vitro cell line models of idiopathic pulmonary fibrosis. Pharmazie, 75 (8),371-374頁 (共著) 2020/08
論文	呼吸器疾患治療のための薬物の肺内動態および肺組織分布特性の解明薬学雑誌. 140 (3),345-354頁 (単著) 2020/03
論文	Intratumoral delivery and therapeutic efficacy of nanoparticle-encapsulated anti-tumor siRNA following intrapulmonary administration for potential treatment of lung cancer. Pharm Dev Technol. 24 (9),1095-1103頁 (共著) 2019/09
論文	Evaluation of various tissue-clearing techniques for the three-dimensional visualization of liposome distribution in mouse lungs at the alveolar scale Int. J. Pharm.. 562,,218-227頁 (共著) 2019/05
論文	Usability of theophylline extended-release dry syrups. Generic Med. 14 (4),175-179頁 (共著) 2018/11
論文	Taste and dissolution of theophylline extended-release dry syrups. J. Generic Med. 14 (3),117-121頁 (共著) 2018/09
論文	The effect of dexmedetomidine on oral mucosal blood flow and the absorption of lidocaine. Anesth. Prog. 65 (3),168-176頁 (共著) 2018/09
論文	Facile and sensitive HPLC-UV method for determination of nintedanib in rat plasma. Int. J. Pharm. Pharm. Sci. 10 (6),133-137頁 (共著) 2018/06
論文	テオフィリン徐放性シロップ用剤の製剤物性および服用性の一例. 応用薬理 94 (3/4.),53-57頁 (共著) 2018/04
論文	Tissue-clearing techniques enable three-dimensional visualization of aerosolized model compound and lung structure at the alveolar scale. Biol. Pharm. Bull. 41,,24-28頁 (共著) 2018/01
論文	Aerosolized liposomes with dipalmitoyl phosphatidylcholine enhance pulmonary absorption of encapsulated insulin compared with co-administrated insulin. Drug Dev. Ind. Pharm, 43 (11),1892-1898頁 (共著) 2017/11
論文	Inhibitory effect of young barley grass extract powder on body weight increase and visceral fat accumulation in mice fed a high-fat diet,. Pharmacometrics, 93 (1/2.),13-18頁 (共著) 2017/10
論文	Evaluation of permeability alteration and epithelial-mesenchymal transition induced by transforming growth factor-β1 in A549, NCI-H441, and Calu-3 cells: development of an in vitro model of respiratory epithelial cells in idiopathic pulmonary fibrosis. J Pharmacol Toxicol Methods, 86,,19-27頁 (共著) 2017/07
論文	Storage stability of serum formulations containing ofloxacin for autologous serum eardrop therapy. Pharmazie, 72 (3),139-142頁 (共著) 2017/03
論文	フェキソフェナジンの消化管吸収における配合薬プソイドエフェドリン及び栄養成分の影響. 応用薬理 91 (3/4.),69-76頁 (共著) 2016/11
論文	Sustained distribution of aerosolized PEGylated liposomes in epithelial lining fluid on alveolus surface. Drug Deliv. Transl. Res., 6,,565-571頁 (共著) 2016/10
論文	Tumor distribution and anti-tumor effect of doxorubicin following intrapulmonary administration to mice with metastatic lung tumor. J Drug Deliv Sci Technol. 33.,143-148頁 (共著) 2016/06
論文	タムスロシン塩酸塩口腔内崩壊錠0.1mgの製剤品質および服用性の臨床的評価ジェネリック研究. 10 (1),27-34頁 (共著) 2016/06
論文	Alteration in intrapulmonary pharmacokinetics of aerosolized model compounds due to disruption of the alveolar epithelial barriers following bleomycin-induced pulmonary fibrosis in rats. J. Pharm. Sci. 105 (3),1327-1334頁 (共著) 2016/03
論文	ドライシロップ剤の使用者は「味」と「水との混ざりやすさ」を重視する小児科診療. 79 (1),128-132頁 (共著) 2016/01
論文	テオフィリン徐放錠の薬物溶出特性とin silico血中濃度推移シミュレーション臨床医薬. 31 (9),835-841頁 (共著) 2015/09
論文	簡易懸濁法の実施が困難な低分散性固形医薬品に対するバッグ型注入器の有用性医学と薬学. 72 (8),1371-1378頁 (共著) 2015/07
論文	Pharmacokinetic evaluation of tissue distribution of pirfenidone and its metabolites for idiopathic pulmonary fibrosis therapy. Biopharm. Drug Dispos. 36 (4),205-215頁 (共著) 2015/05
論文	Efficient delivery to human lung fibroblasts (WI-38) of pirfenidone incorporated into liposomes modified with truncated basic fibroblast growth factor and its inhibitory effect on collagen synthesis in idiopathic pulmonary fibrosis. Biol. Pharm. Bull. 28 (2),270-276頁 (共著) 2015/02
論文	Involvement of intestinal permeability in the oral absorption of clarithromycin and telithromycin. Biopharm. Drug Dispos. 35 (6),321-329頁 (共著) 2014/09
論文	Aerosol-based efficient delivery of azithromycin to alveolar macrophages for treatment of respiratory infections. Pharm Dev Technol. 18 (6),1361-1365頁 (共著) 2013/12
論文	Dexmedetomidine decreases the oral mucosal blood flow. Br. J. Oral Maxillofac. Surg. 51 (8),928-931頁 (共著) 2013/11
論文	Possible involvement of pirfenidone metabolites in the antifibrotic action of a therapy for idiopathic pulmonary fibrosis. Biol. Pharm. Bull.3 36 (10),1525-1527頁 (共著) 2013/10
論文	Subcellular distribution of azithromycin and clarithromycin in rat alveolar macrophages (NR8383) in vitro. Biol. Pharm. Bull. 36 (9),1494-1499頁 (共著) 2013/09
論文	Enantioselective uptake of fexofenadine by Caco-2 cells as model intestinal epithelial cells. J. Pharm. Pharmacol. 65 (1),22-29頁 (共著) 2013/01
論文	Transport characteristics of clarithromycin, azithromycin and telithromycin, antibiotics applied for treatment of respiratory infections, in Calu-3 cell monolayers as model lung epithelial cells. Pharmazie, 67 (5),389-393頁 (共著) 2012/10
論文	Aerosol-based efficient delivery of clarithromycin, a macrolide antimicrobial agent, to lung epithelial lining fluid and alveolar macrophages for treatment of respiratory infections. J. Aerosol Med. Pulm. Drug Deliv. 25 (2),110-115頁 (共著) 2012/04
その他	「雑誌掲載」呼吸器感染症の治療を目的としたマクロライド系抗菌薬の肺内動態及び肺移行機構に関する研究化学療法の領域,27, 2011,2754-2761頁 (共著) 2011/11
論文	Distribution characteristics of clarithromycin and azithromycin, macrolide antimicrobial agents used for treatment of respiratory infection, in lung epithelial lining fluid and alveolar macrophages. Biopharm. Drug Dispos. 32 (7),389-397頁 (共著) 2011/07
論文	Efficient drug delivery to lung epithelial lining fluid by aerosolization of ciprofloxacin incorporated into PEGylated liposomes for treatment of respiratory infections. Drug Dev. Ind. Pharm. 37 (4),367-372頁 (共著) 2011/04
論文	Aerosol-based efficient delivery of telithromycin, a ketolide antimicrobial agent, to lung epithelial lining fluid and alveolar macrophages for treatment of respiratory infections Drug Dev. Ind. Pharm. 36 (7),861-866頁 (共著) 2010/07
論文	呼吸器感染症治療薬であるマクロライド及びケトライド系抗菌薬の肺組織移行特性に関する研究（博士論文） (単著) 2010/03
論文	Effect of surface-mannose modification on aerosolized liposomal delivery to alveolar macrophages. Drug Dev. Ind. Pharm. 36 (1),102-107頁 (共著) 2010/01
論文	Intracellular pharmacokinetics of telithromycin, a ketolide antibiotic, in alveolar macrophages. J PharmPharmacol. 62 (1),71-75頁 (共著) 2010/01
論文	Distribution characteristics of telithromycin, a novel ketolide antimicrobial agent applied for treatment of respiratory infection, in lung epithelial lining fluid and alveolar macrophages. Drug MetabPharmacokinet. 24 (5),411-417頁 (共著) 2009/10
著書	多面的症例解析演習-基礎分野・臨床分野から症例を俯瞰して- 京都廣川書店 (共著) 2014/04
著書	徹底解説　薬物動態の数学　第2版 (共著) 2013/04