柏倉　淳一｜薬学部薬学科｜教員紹介｜北海道科学大学研究者データベース

カシワクラ　ジュンイチ Junichi Kashiwakura
柏倉　淳一

所属北海道科学大学薬学部薬学科

職種教授

著書・論文歴
著書	Monomeric IgE and mast cell development, survival and function. Advances in Experimental Medicine and Biology 716,29-46頁 (共著) 2011
論文	The role of Signal-transducing adaptor protein-1 for T cell activation and pathogenesis of autoimmune demyelination and airway inflammation The Journal of Immunology 212,951-961頁 (共著) 2024/03
論文	Potential therapeutic applications of targeting signal-transducing adaptor protein-2 in autoimmune diseases Exploration of Immunology 3,604 (共著) 2023/12
論文	T細胞活性化応答に対する新規阻害剤開発およびその効果ファルマシア 59 (12),1101 (共著) 2023/12
論文	STAP-2 negatively regulates BCR-mediated B cell activation by recruiting tyrosine-protein kinase CSK to LYN. FEBS letters 597,2433-2445頁 (共著) 2023/10
論文	STAP-2-Derived Peptide Suppresses TCR-Mediated Signals to Initiate Immune Responses The Journal of Immunology (共著) 2023/09
論文	IgE依存性好塩基球活性化反応に対するプロポリスの効果アレルギー 72 (3),233-236頁 (単著) 2023/06
論文	A peptide derived from adaptor protein STAP-2 inhibits tumor progression by downregulating epidermal growth factor receptor signaling. Journal of Biological Chemistry 299 (1),102724 (共著) 2023/01
論文	Signal-transducing adaptor protein-2 modulates T-cell functions Explor Immunol. 2,771-782頁 (共著) 2022/12
論文	The Functional Properties and Physiological Roles of Signal-Transducing Adaptor Protein-2 in the Pathogenesis of Inflammatory and Immune Disorders. Biomedicines 10 (12),3079 (共著) 2022/11
論文	Identification of RPL15 60S Ribosomal Protein as a Novel Topotecan Target Protein That Correlates with DAMP Secretion and Antitumor Immune Activation. Journal of Immunology 209 (1),171-179頁 (共著) 2022/07
論文	Regulation of NFKBIZ gene promoter activity by STAT3, C/EBPβ, and STAT1. Biochemical and Biophysical Research Communications 613,61-66頁 (共著) 2022/07
論文	STAP-2 Is a Novel Positive Regulator of TCR-Proximal Signals. Journal of Immunology 209 (1),57-68頁 (共著) 2022/07
論文	A novel intramolecular negative regulation of mouse Jak3 activity by tyrosine 820. International Immunology 34 (6),303-312頁 (共著) 2022/06
論文	Porcine Placenta Extract Enhances Ceramide Synthase 3 Expression through the PPARδ/ILK/Akt/mTOR/STAT3 Pathway. Journal of Cosmetics, Dermatological Sciences and Applications 12,131-144頁 (共著) 2022/06
論文	Pivotal Role of Signal-Transducing Adaptor Protein-2 in Pathogenesis of Autoimmune Hepatitis. Biological & Pharmaceutical Bulletin 44 (12),1898-1901頁 (共著) 2021/12
論文	Signal-transducing adaptor protein-2 has a nonredundant role for IL-33-triggered mast cell activation. Biochemical and Biophysical Research Communications 572,80-85頁 (共著) 2021/10
論文	Propolis suppresses cytokine production in activated basophils and basophil-mediated skin and intestinal allergic inflammation in mice. Allergology International 70 (3),360-367頁 (共著) 2021/07
論文	Positive interactions between STAP-1 and BCR-ABL influence chronic myeloid leukemia cell proliferation and survival. Biochemical and Biophysical Research Communications 556,185-191頁 (共著) 2021/06
論文	CD47 promotes T-cell lymphoma metastasis by up-regulating AKAP13-mediated RhoA activation. International Immunology 33 (5),273-280頁 (共著) 2021/04
論文	Higher PGD2 production by synovial mast cells from rheumatoid arthritis patients compared with osteoarthritis patients via miR-199a-3p/prostaglandin synthetase 2 axis. Scientific Reports 11 (1),5738 (共著) 2021/03
論文	Signal-transducing adaptor protein-2 delays recovery of B lineage lymphocytes during hematopoietic stress. Haematologica 106 (2),424-436頁 (共著) 2021/02
論文	Graft-versus-host disease develops in mice transplanted with lymphocyte-depleted bone marrow cells from signal-transducing adaptor protein-2 transgenic mice. Biochemical and Biophysical Research Communications 537,118-124頁 (共著) 2021/01
論文	Implication of NF-kappaB activation on Ozon-induced HO-1 activation. BPB Reports 4 (2),59-63頁 (共著) 2021
論文	Expression of signal-transducing adaptor protein-1 attenuates experimental autoimmune hepatitis via down-regulating activation and homeostasis of invariant natural killer T cells. PLOS ONE 15 (11),e0241440 (共著) 2020/11
論文	Signal-transducing adapter protein-1 is required for maintenance of leukemic stem cells in CML. Oncogene 39 (34),5601-5615頁 (共著) 2020/08
論文	The mechanism of Tyk2 deficiency-induced immunosuppression in mice involves robust IL-10 production in macrophages. Cytokine 130,155077 (共著) 2020/03
論文	Dimethyl fumarate dampens IL-17-ACT1-TBK1 axis-mediated phosphorylation of Regnase-1 and suppresses IL-17-induced IκB-ζ expression. Biochemical and Biophysical Research Communications 521 (4),957-963頁 (共著) 2020/01
論文	The basophil-IL-4-mast cell axis is required for food allergy. Allergy 74 (10),1992-1996頁 (共著) 2019/10
論文	Differentiation between control subjects and patients with chronic spontaneous urticaria based on the ability of anti-IgE autoantibodies (AAbs) to induce FcεRI crosslinking, as compared to anti-FcεRIα AAbs. Allergology International 68 (3),342-351頁 (共著) 2019/07
論文	Mast cells play role in wound healing through the ZnT2/GPR39/IL-6 axis. Scientific Reports 9 (1),10842 (共著) 2019/07
論文	IκB-ζ Expression Requires Both TYK2/STAT3 Activity and IL-17-Regulated mRNA Stabilization. ImmunoHorizons 3 (5),172-185頁 (共著) 2019/05
論文	STAP-2 positively regulates FcεRI-mediated basophil activation and basophil-dependent allergic inflammatory reactions. International Immunology 31 (5),349-356頁 (共著) 2019/04
論文	Characterization of human decidual mast cells and establishment of a culture system. Allergology International 67S,S18-S24頁 (共著) 2018/09
論文	Crystal structures of murine and human Histamine-Releasing Factor (HRF/TCTP) and a model for HRF dimerisation in mast cell activation. Molecular Immunology 93,216-222頁 (共著) 2018/01
論文	Histamine-releasing factor enhances food allergy. Journal of Clinical Investigation 127 (12),4541-4553頁 (共著) 2017/12
論文	STAP-2 protein promotes prostate cancer growth by enhancing epidermal growth factor receptor stabilization. Journal of Biological Chemistry 292 (47),19392-19399頁 (共著) 2017/11
論文	The dual regulation of substance P-mediated inflammation via human synovial mast cells in rheumatoid arthritis. Allergology International 66S,S9-S20頁 (共著) 2017/09
論文	Biochanin A enhances RORγ activity through STAT3-mediated recruitment of NCOA1. Biochemical and Biophysical Research Communications 489 (4),503-508頁 (共著) 2017/08
論文	A Novel α9 Integrin Ligand, XCL1/Lymphotactin, Is Involved in the Development of Murine Models of Autoimmune Diseases. Journal of Immunology 199 (1),82-90頁 (共著) 2017/07
論文	STAP-2 interacts with Pyk2 and enhances Pyk2 activity in T-cells. Biochemical and Biophysical Research Communications 488 (1),81-87頁 (共著) 2017/06
論文	Expression of TCTP-Related Genes. J. Genet. Disor. Genet. Rep. 6 (2) (共著) 2017/05
論文	アレルギー炎症反応におけるヒスタミン遊離因子の役割薬学雑誌 137 (5),517-521頁 (共著) 2017/05
論文	アレルギー研究の最前線薬学雑誌 137 (5),493-494 (共著) 2017/05
論文	Interleukin-17A expression in human synovial mast cells in rheumatoid arthritis and osteoarthritis. Allergology international : official journal of the Japanese Society of Allergology 65 Suppl,S11-6 (共著) 2016/09
論文	MIP-1α level in nasopharyngeal aspirates at the first wheezing episode predicts recurrent wheezing. The Journal of allergy and clinical immunology 137 (3),774-81 (共著) 2016/03
論文	アレルギー炎症におけるヒスタミン遊離因子の役割生化学 87 (6),766-769頁 (単著) 2015/12
論文	Expression of Mas-related gene X2 on mast cells is upregulated in the skin of patients with severe chronic urticaria. Journal of Allergy and Clinical Immunology 134 (3),622-633頁 (共著) 2014/09
論文	Signal-transducing adaptor protein-2 controls the IgE-mediated, mast cell-mediated anaphylactic responses. Journal of Immunology 192 (8),3488-3495頁 (共著) 2014/04
論文	Highly expressed cytoplasmic FcεRIβ in human mast cells functions as a negative regulator of the FcRγ-mediated cell activation signal. Clinical and Experimental Allergy 44 (2),238-249頁 (共著) 2014/02
論文	Critical role for mast cell Stat5 activity in skin inflammation. Cell Reports 6 (2),366-376頁 (共著) 2014/01
論文	Histamine-releasing factor and immunoglobulins in asthma and allergy. Allergy, Asthma & Immunology Research 6 (1),6-12頁 (共著) 2014/01
論文	Interleukin-33 synergistically enhances immune complex-induced tumor necrosis factor alpha and interleukin-8 production in cultured human synovium-derived mast cells. International Archives of Allergy and Immunology 161 Suppl 2,32-36頁 (共著) 2013/05
論文	Significantly high levels of anti-dsDNA immunoglobulin E in sera and the ability of dsDNA to induce the degranulation of basophils from chronic urticaria patients. International Archives of Allergy and Immunology 161 Suppl 2,154-158頁 (共著) 2013/05
論文	Interaction between conjunctival epithelial cells and mast cells induces CCL2 expression and piecemeal degranulation in mast cells. Investigative Ophthalmology & Visual Science 54 (4),2465-2473頁 (共著) 2013/04
論文	Human CD300C delivers an Fc receptor-γ-dependent activating signal in mast cells and monocytes and differs from CD300A in ligand recognition. Journal of Biological Chemistry 288 (11),7662-7675頁 (共著) 2013/03
論文	Activation of human synovial mast cells from rheumatoid arthritis or osteoarthritis patients in response to aggregated IgG through Fcγ receptor I and Fcγ receptor II. Arthritis and Rheumatism 65 (1),109-119頁 (共著) 2013/01
論文	Most Highly Cytokinergic IgEs Have Polyreactivity to Autoantigens. Allergy, Asthma & Immunology Research 4 (6),332-340頁 (共著) 2012/11
論文	The interaction between Lyn and FcεRIβ is indispensable for FcεRI-mediated human mast cell activation. Allergy 67 (10),1241-1249頁 (共著) 2012/10
論文	ヒトマスト細胞の多様性アレルギー 61 (6),792-797頁 (共著) 2012/06
論文	Omalizumab inhibits acceleration of FcεRI-mediated responsiveness of immature human mast cells by immunoglobulin E. Annals of Allergy, Asthma & Immunology 108 (3),188-194頁 (共著) 2012/03
論文	Histamine-releasing factor has a proinflammatory role in mouse models of asthma and allergy. Journal of Clinical Investigation 122 (1),218-228頁 (共著) 2012/01
論文	Phospholipase C-β3 regulates FcɛRI-mediated mast cell activation by recruiting the protein phosphatase SHP-1. Immunity 34 (6),893-904頁 (共著) 2011/06
論文	JNK1 controls mast cell degranulation and IL-1{beta} production in inflammatory arthritis. Proceedings of the National Academy of Sciences of the United States of America 107 (51),22122-22127頁 (共著) 2010/12
論文	FcepsilonRI beta-chain ITAM amplifies PI3K-signaling to ensure synergistic degranulation response via FcepsilonRI and adenosine receptors. European Journal of Immunology 40 (4),1205-1217頁 (共著) 2010/04
論文	Polyclonal IgE induces mast cell survival and cytokine production. Allergology international 58 (3),411-419頁 (共著) 2009/09
論文	IgE accelerates in vitro development of mast cells and modifies their phenotype. Journal of Leukocyte Biology 84 (2),357-367頁 (共著) 2008/08
論文	Gene expression profiling of human mast cell subtypes: an in silico study. Allergology international 55 (2),173-179頁 (共著) 2006/06
論文	T cell proliferation by direct cross-talk between OX40 ligand on human mast cells and OX40 on human T cells: comparison of gene expression profiles between human tonsillar and lung-cultured mast cells. Journal of immunology 173 (8),5247-5257頁 (共著) 2004/10
論文	Abnormal killer inhibitory receptor expression on natural killer cells in patients with Behçet's disease. Rheumatology international 24 (4),212-216頁 (共著) 2004/07
論文	Th1-dominant shift of T cell cytokine production, and subsequent reduction of serum immunoglobulin E response by administration in vivo of plasmid expressing Txk/Rlk, a member of Tec family tyrosine kinases, in a mouse model. Clinical and experimental allergy 34 (6),965-970頁 (共著) 2004/06
論文	Human mast cell activation through Fc receptors and Toll-like receptors. Allergol. Int. 53 (3),227-233頁 (共著) 2004
論文	Identification of specific gene expression profiles in human mast cells mediated by Toll-like receptor 4 and FcepsilonRI. Blood 102 (7),2547-2554頁 (共著) 2003/10
論文	Preferential expression of B7.2 (CD86), but not B7.1 (CD80), on B cells induced by CD40/CD40L interaction is essential for anti-DNA autoantibody production in patients with systemic lupus erythematosus. Clinical and experimental rheumatology 21 (1),71-77頁 (共著) 2003/01
論文	Evidence of autophosphorylation in Txk: Y91 is an autophosphorylation site. Biological & pharmaceutical bulletin 25 (6),718-21 (共著) 2002/06
論文	Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription. Journal of immunology (Baltimore, Md. : 1950) 168 (5),2365-2370頁 (共著) 2002/03
論文	Analysis of Differentiation Marker Proteins in Helper T Cell Subtypes, Th1 and Th2 Journal of Health Science 47 (3),288-295頁 (共著) 2001/05
論文	Txk, a nonreceptor tyrosine kinase of the Tec family, is expressed in T helper type 1 cells and regulates interferon gamma production in human T lymphocytes. The Journal of Experimental Medicine 190 (8),1147-1154頁 (共著) 1999/10
論文	The female X-inactivation mosaic in SLE. Immunology today 20 (3),152-153頁 (共著) 1999/03