Researchers & Faculty
Japanese
Kosuke Otani
Department / Course
Hokkaido University of Science Faculty of Pharmaceutical Sciences Department of Pharmacy
Job
Lecturer
Book and thesis
Papers
A selective eukaryotic elongation factor 2 kinase inhibitor, A484954 lowered blood glucose in Zucker fatty diabetes mellitus rat. Journal of pharmacological sciences 158 (3),pp.270-275 (Co-authored) 2025/07
Papers
Senescent cardiac fibroblasts-derived extracellular vesicles induced autophagy in cardiac fibroblasts via suppression of ras homolog enriched in brain like 1. Journal of pharmacological sciences 158 (1),pp.1-7 (Co-authored) 2025/05
Papers
Development of an Effective Isolation Method for Plasma Extracellular Vesicles Excluding Lipoproteins by Precipitation With Polyethylene Glycol. Journal of extracellular biology 4 (4),pp.e70047 (Co-authored) 2025/04
Papers
The eukaryotic elongation factor 2 kinase inhibitor, A484954, induces hypoglycaemic and hypotensive effects. British journal of pharmacology 182 (8),pp.1823-1835 (Co-authored) 2025/04
Papers
Minocycline prevents monocrotaline-induced pulmonary hypertension through the attenuation of endothelial dysfunction and vascular wall thickening. Journal of pharmacological sciences 157 (1),pp.39-44 (Co-authored) 2025/01
Papers
Protective function of the voltage-gated potassium channel Kv11.3 in a mouse model of cardiac ischemia/reperfusion injury. PloS one 20 (5),pp.e0323428 (Co-authored) 2025
Papers
Alteration of reactivity in isolated mesenteric artery from Zucker fatty diabetes mellitus rats. Journal of pharmacological sciences 156 (1),pp.38-44 (Co-authored) 2024/09
Papers
Human omentin-1 reduces vascular insulin resistance and hypertension in Otsuka Long-Evans Tokushima Fatty rats. Naunyn-Schmiedeberg's archives of pharmacology 397 (5),pp.3379-3387 (Co-authored) 2024/05
Papers
Eukaryotic elongation factor 2 kinase inhibitor, A484954 induced diuresis via nitric oxide production in spontaneously hypertensive rats. The Journal of veterinary medical science 85 (12),pp.1314-1318 (Co-authored) 2023/12
Papers
Autocrine role of senescent cardiac fibroblasts-derived extracellular vesicles. The Journal of veterinary medical science 85 (11),pp.1157-1164 (Co-authored) 2023/11
Papers
Human Omentin-1 Administration Ameliorates Hypertensive Complications without Affecting Hypertension in Spontaneously Hypertensive Rats. International journal of molecular sciences 24 (4) (Co-authored) 2023/02
Papers
Chemerin fragments show different effects on systemic blood pressure dependent on carboxyl-terminal cleavage site. The Journal of veterinary medical science 84 (10),pp.1352-1357 (Co-authored) 2022/09
Papers
Eukaryotic elongation factor 2 kinase inhibitor, A484954 inhibits perivascular sympathetic nerve stimulation-induced vasoconstriction in isolated renal artery. European journal of pharmacology 926,pp.175042 (Co-authored) 2022/07
Papers
Cardiovascular Characteristics of Zucker Fatty Diabetes Mellitus Rats, an Animal Model for Obesity and Type 2 Diabetes. International journal of molecular sciences 23 (8) (Co-authored) 2022/04
Papers
Chemerin-9 stimulates migration in rat cardiac fibroblasts in vitro. European journal of pharmacology 912,pp.174566 (Co-authored) 2021/12
Papers
Eukaryotic elongation factor 2 kinase inhibitor, A484954 induces diuretic effect via renal vasorelaxation in spontaneously hypertensive rats. European journal of pharmacology 913,pp.174637 (Co-authored) 2021/12
Papers
Chemokine-like Receptor 1 in Brain of Spontaneously Hypertensive Rats Mediates Systemic Hypertension. International journal of molecular sciences 22 (21) (Co-authored) 2021/10
Papers
A single injection of periostin decreases cardiac voltage-gated Na+ channel in rat ventricles. The Journal of veterinary medical science 83 (6),pp.997-1003 (Co-authored) 2021/07
Papers
Age-dependent increase in activity of eukaryotic elongation factor 2 kinase in mesenteric arteries from spontaneously hypertensive rats. The Journal of veterinary medical science 83 (1),pp.42-47 (Co-authored) 2021/01
Papers
Preventive Effect of Canstatin against Ventricular Arrhythmia Induced by Ischemia/Reperfusion Injury: A Pilot Study. International journal of molecular sciences 22 (3) (Co-authored) 2021/01
Papers
Development of basic research toward clinical application of cleaved fragment of type IV collagen,pp.282-287 (Co-authored) 2021
Papers
Decreased Expression of Canstatin in Rat Model of Monocrotaline-Induced Pulmonary Arterial Hypertension: Protective Effect of Canstatin on Right Ventricular Remodeling. International journal of molecular sciences 21 (18) (Co-authored) 2020/09
Papers
Plasma small extracellular vesicles in hypertensive rats impair reactivity of isolated blood vessels. The Journal of veterinary medical science 82 (7),pp.897-902 (Co-authored) 2020/07
Papers
Chemerin-9-induced contraction was enhanced through the upregulation of smooth muscle chemokine-like receptor 1 in isolated pulmonary artery of pulmonary arterial hypertensive rats. Pflugers Archiv : European journal of physiology 472 (3),pp.335-342 (Co-authored) 2020/03
Papers
Small extracellular vesicles from rat plasma promote migration and proliferation of vascular smooth muscle cells. The Journal of veterinary medical science 82 (3),pp.299-306 (Co-authored) 2020/03
Papers
Optimal Isolation Method of Small Extracellular Vesicles from Rat Plasma. International journal of molecular sciences 20 (19) (Co-authored) 2019/09
Papers
Plasma exosomes regulate systemic blood pressure in rats. Biochemical and biophysical research communications 503 (2),pp.776-783 (Co-authored) 2018/09
Papers
Diverse distribution of tyrosine receptor kinase B isoforms in rat multiple tissues. The Journal of veterinary medical science 79 (9),pp.1516-1523 (Co-authored) 2017/09
Papers
Vasculo-protective effect of BMS-309403 is independent of its specific inhibition of fatty acid-binding protein 4. Pflugers Archiv : European journal of physiology 469 (9),pp.1177-1188 (Co-authored) 2017/09
Papers
Expression pattern and function of tyrosine receptor kinase B isoforms in rat mesenteric arterial smooth muscle cells. Biochemical and biophysical research communications 467 (4),pp.683-9 (Co-authored) 2015/11
Papers
Death-associated protein kinase 3 mediates vascular structural remodelling via stimulating smooth muscle cell proliferation and migration. Clinical science (London, England : 1979) 127 (8),pp.539-48 (Co-authored) 2014/10